Abstract
Objective:To estimate the hepatoprotective effects of the methanolic seed extract of Eugenia jambolana Lam. (Myrtaceae), in Wistar albino rats treated with carbon tetrachloride (CCl4).Materials and Methods:Liver damage in rats treated with CCl4 (1ml/kg/Bw, administered subcutaneously, on alternate days for one week) was studied by assessing parameters such as serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), alkaline phosphatase (ALP), acid phosphatase (ACP) and bilirubin (total and direct). The effect of co-administration of Eugenia jambolana Lam. (doses 100, 200 and 400 mg/kg p. o.) on the above parameters was investigated. These biochemical observations were supplemented by weight and histological examination of liver sections. Liv.52® was used as positive control. Data were analyzed by one way ANOVA, followed by Scheff's/Dunnett's test.Results:Administration of Eugenia jambolana Lam. (doses 100, 200 and 400 mg/kg p. o.) significantly prevented carbon tetrachloride induced elevation of serum SGOT, SGPT, ALP, ACP and bilirubin (total and direct) level. Histological examination of the liver section revealed hepatic regeneration, after administration of various doses of Eugenia jambolana Lam. The results were comparable to that of Liv.52®.Conclusion:The study suggests preventive action of Eugenia jambolana Lam. in carbon tetrachloride induced liver toxicity. Hepatic cell regeneration process was dose dependent.
Highlights
The liver, in vertebrate body, performs many vital functions, including metabolic and detoxification activities
To estimate the hepatoprotective effects of the methanolic seed extract of Eugenia jambolana Lam. (Myrtaceae), in Wistar albino rats treated with carbon tetrachloride (CCl4)
Materials and Methods: Liver damage in rats treated with CCl4 (1ml/kg/Bw, administered subcutaneously, on alternate days for one week) was studied by assessing parameters such as serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), alkaline phosphatase (ALP), acid phosphatase (ACP) and bilirubin
Summary
The liver, in vertebrate body, performs many vital functions, including metabolic and detoxification activities. A number of chemical agents and routine drugs produce cellular as well as metabolic liver injury. (Myrtaceae), popularly known as Jamun, is being widely used to treat liver dysfunctions and diabetes by the traditional practitioners for over many centuries.[1,2,3] The bark of this plant is astringent, antihelmenthic, antipyretic, antidysentric and useful in certain urinary disorders, excessive thirst, hemorrhages, ulcer and vaginal discharges.[4] The juice is helpful in treating inflammation and swelling on the liver and spleen.[5] The chemical constituents of the seed of Eugenia jambolana Lam. are gallic acid, ellagic acid, corilagin, ellagitannins, isoquercetin, quercetin, caffeic acid, ferulic acid, guaiacol, resorcinaldimethyl ether, lignaglucoside, veratrole, β - sitosterol, palmitic acid etc.[1,5]
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