Abstract
The hepatoprotective activity of Conyza bonariensis ethanol extract was studied against paracetamol induced hepatotoxicity in mice. The results showed that an extract of C.B (250 mg/kg and 500 mg/kg) produced (p<0.05) decline in paracetamol induced liver marker enzymes and total bilirubin, but its 750 mg/kg showed remarkable decline in ALT, AST, ALP and TB levels, compared to the reference levels of silymarin and results were supported by histopathology of liver section. So, it is concluded that 750 mg/kg is highly potent dose of ethanol extract of Conyza bonariensis and this potential may be due to the presence of the active constituent: qurecetin and chromatogram by HPLC confirmed its presence.
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