Hepatoprotective Activity of Curcuma Vamana Ethanolic Rhizome Extract Against Paracetamol and CCl4 Induced Hepatotoxicity in Albino Rats

Abstract

Objective The current study evaluated the hepatoprotective activity of Curcuma vamana ethanolic rhizome extract against paracetamol and CCl4 induced hepatotoxicity in a rat model.Materials and methods Hepatoprotective activity of Curcuma vamana was evaluated on CCl4 and paracetamol induced hepatotoxicity in rats by measuring levels of biochemical enzymes in the serum and tissue homogenate and histopathological assessment.Results The in-vivo hepatoprotective activity of different doses 100 200 400mgkg of ethanol rhizome extract of Curcuma vamana was carried out against CCl4 and paracetamol induced hepatotoxicity in rats. During the study it was found the EECV showed significant plt0.001 decrease in the biochemical enzymes in serum and tissue homogenate such as AST ALT ALP TB LDL-cholesterol Total cholesterols LPO and significantly increases the HDL- cholesterol Total protein Glucose GSH CAT SOD and total thiols levels as compared to the control groups were supported these findings further histopathological studies. Thus the present finding provides scientific evidence of to the ethno-medicinal value of rhizome of Curcuma vamana in liver disorders.Conclusion In conclusion Curcuma vamana possesses a significant hepatoprotective activity against CCl4 and paracetamol induced hepatotoxicity in rats.