Abstract
The present study investigated the protective role of chitosannano-carriers loaded with the ethyl acetate extract of a Stenotrophomonas sp. bacteria associated with the Red Sea Sponge Amphimedon ochracea CCl4 induced hepatic damage in rats using the hepatological parameters. Healthy 80 male Sprague-Dawley rats weighed 50 - 80 gm were used. The animals were randomly divided into eight groups. Serum ALT and AST, albumin, direct buluibin and histopathological examinations were investigated. Liver targeting of the drugs has been achieved after administration of drug loaded spherical particles. This mode of administration of drugs enhanced its overall delivery to the liver via passive targeting. The present study revealed that the treatment with ethyl acetate bacterial extract (10 mg/Kg body weight) protected rats from hepatotoxic action of CCl4. Usage of chitosan nanoparticles loaded with the bacterial extract as a drug delivery system has greatly improved the curative effect of bacterial extract. Moreover, histopathological studies showed marked reduction in fatty degeneration and centrizonal necrosis in animals receiving the nano-chitosan loaded with the bacterial extract along with ethanol compared to the control group.
Highlights
Liver is one of the largest organs in human body and the chief site for intense metabolism and excretion
The present study investigated the protective role of chitosannano-carriers loaded with the ethyl acetate extract of a Stenotrophomonas sp. bacteria associated with the Red Sea Sponge Amphimedon ochracea CCl4 induced hepatic damage in rats using the hepatological parameters
Histopathological studies showed marked reduction in fatty degeneration and centrizonal necrosis in animals receiving the nano-chitosan loaded with the bacterial extract along with ethanol compared to the control group
Summary
Liver is one of the largest organs in human body and the chief site for intense metabolism and excretion It has a surprising role in the maintenance, performance and regulating homeostasis of the body. In contrast to the terrestrial environment where plants are the most prolific sources of natural products, this leading position in the sea is taken by invertebrates such as sponges, tunicates, bryozoans, or mollusks, with sponges being the most prolific sources of natural products [6] The wealth of their secondary metabolites has been related to the role of chemical defense played by these constituents; such ecological function is believed to be crucial for the survival of the producer organisms, which are soft-bodied, sessile or slow-moving animals, lacking, in most cases, morphological defense structures such as shells or spines [7]. One of the approaches is the use of colloidal drug carriers that can provide site specific or targeted drug delivery combined with optimal drug release profiles
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