Abstract
<em></em>Effects of phytopreparation from a plant of <em>Limonium gmelinii</em> were studied on livers of white breedless rats at chronic impact of cadmium sulfate and carbon tetrachloride. It was established the administration of cadmium sulfate during six months caused chronic hepatitis, while the simultaneous administration of preparation from <em>Limonium gmelinii</em> and cadmium sulfate did not result of destructive changes in a liver. Chronic intoxication of the animals by carbon tetrachloride during six months caused progressive postnecrotic cirrhosis. The simultaneous administration of phytopreparation and carbon tetrachloride caused postnecrotic fibrosis in the central part of hepatic lobule only. Not only dystrophic and necrobiotic processes also numerous inflammatory cell infiltrates were observed in hepatic parenchyma of animals which were treated by cadmium sulfate and carbon tetrachloride, while it was not observed at animals which were medicated with phytopreparation. Thus, on the basis of the data was concluded about hepatoprotective action of phytopreparation from<em> Limonium gmelinii</em>.
Highlights
Industrial pollution of an environment, wide application of chemicals and drugs has resulted to increase number of chronic liver diseases are caused by ksenobiotics [1]
Experiments for the Limonium preparation influence were conducted on livers of white breedless rats at chronic intoxication of cadmium sulfate and carbon tetrachloride
We were not observing necrosis of hepatocytes and inflammatory infiltrates at rats of this group (Fig. 4). This fact testifies to positive action of phytopreparation at cadmium sulfate administration
Summary
Industrial pollution of an environment, wide application of chemicals and drugs has resulted to increase number of chronic liver diseases are caused by ksenobiotics [1]. The development of drugs having hepatoprotective properties is urgent. There are such hepatoprotectors in clinical practice : 1) antioxidants; 2) inhibitors of microsomal enzymes that reduce the injuring metabolites formation; 3) the preparations which recover membranous; 4) inductors of metabolic processes raising regenerative potential of hepatic parenchyma [3]. Rich and various floras of Kazakhstan which numbers more than 100 medicinal plants, can be a source of accessible and cheap raw material for manufacture of the vital medicinal preparations with hepatoprotective action. For introduction in medical practice the most perspective plants
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