Abstract
Hepatokines are specialized secretory proteins of the liver that play pivotal role in regulation of metabolic homeostasis as well as ensure crosstalk of liver to other organs. In recent years, the correlation of hepatokines and hepatic diseases has been exhibited, positively. Several stimuli, particularly hepatic steatosis provoke dysregulation in metabolic homeostasis and subsequently, pathogenesis of liver diseases that influence expression and release of hepatokines. In this review, we have interlinked the association of hepatic steatosis, a hallmark of obesity, to liver and liver-derived hepatokines. Furthermore, we summarized briefly the impact of several etiologically and epidemiologically important hepatokines, including Fetuin-A, fibroblast growth factor-21 (FGF-21), selenoprotein P, sexual hormone binding globulin (SHBG), angiopoietin like 4 (ANGPTL4) and leukocyte cell-derived chemotaxin (LECT2), in health and disease. Such hepatokines could serve as non-invasive biomarkers of early stages of liver pathogenesis and might contribute in improving patient safety profile for screening purposes and expediting drug development.
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