Abstract

There is a need for new therapies for support of liver function. Hepatocyte transplantation (Htx) has been used to support liver function in acute or chronic liver disease and as a “cellular therapy” for metabolic liver disease. Transplants in human patients mirror the results of animal studies and indicate that Htx increases survival of acute liver failure patients and partially or completely corrects metabolic liver disease. These promising results suggest that Htx could be an inexpensive and effective treatment for liver disease. Clinical programs are now established in at least 13 different centers in 9 different countries.

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