Abstract
HGF/SF is a heparin binding polypeptide that stimulates cell proliferation, motility and morphogenesis via activation of it's receptor c-Met tyrosine kinase. It has also been shown that HGF/SF is a potent angiogenic factor in a sponge implant model in rats. To evaluate the potential HGF/SF has to heal chronic cutaneous wounds we have topically applied recombinant murine HGF/SF to full thickness excisional injuries using the diabetes mouse model. The diabetes mouse is the result of a spontaneous mutation in an inbred mouse strain. Homozygote animals (db/db) are obese, hyperglycemic and exhibit impaired cutaneous wound healing compared to their wildtype littermates.
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