Abstract
The toxic degenerative hepatitis induced by Frog Virus 3 in mice is characterized by late cytoplasmic alterations of the hepatocytes as well as early nuclear lesions. These alterations vary according to the dose of virus used. The inoculation of one lethal dose is followed by an alteration of both rough and smooth endoplasmic reticula (appearance of fingerprints and hypertrophy of SER), an accumulation of lipids, and a final necrosis. With high doses of virus (20 LD) lesions of a much more drastic nature can be shown: The RER disrupts and even disappears. Mitochondrial alterations can be seen just before the death of the animals, whereas steatosis and SER hypertrophy have never been observed.
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