Abstract
High resolution cross-sectional imaging techniques means that even small, well-differentiated hepatocellular tumors can also be diagnosed with biopsy. In cirrhotic liver tissue, macroregenerative and dysplastic nodules must be discriminated from hepatocellular cancer (HCC). In non-cirrhotic liver tissue the differential diagnosis includes hepatocellular adenoma, macroregeneratory nodules, fibrolamellar carcinoma, as well as primary tumors and metastases. The diagnostic procedure includes matrix diagnosis of the tumor-bearing liver tissue, cyto- and histomorphologic analysis including capillarization of vascular bed, and adapted immunohistological testing with antibodies which underline possible malignancy or hepatocellular differentiation. Aflow chart for the diagnosis of hepatocellular carcinomas and their mimics on liver biopsies is presented.
Highlights
Abb. 1 8 Hepatozelluläres Karzinom (HCC)mit Cholestase undportovenöserAngioinvasioninderTumorkapsel (a), hellzelliger dysplastischer Fokus im Tumorumfeld (c) mit erhöhter Zelldichte und CD34-negativem sinusoidalem Gefäßbett (b)
Macroregenerative and dysplastic nodules must be discriminated from hepatocellular cancer (HCC)
Dysplastische Foci sind mikroskopisch kleine (
Summary
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