Abstract
BackgroundHepatocellular carcinoma (HCC) is considered the third-leading cause of cancer-related mortality worldwide. Most cases of HCC are usually associated with liver cirrhosis due to various causes such as alcohol or more commonly viral hepatitis. Usually, patients remain asymptomatic for a long time, and symptoms are usually related to the cirrhosis itself or secondary to tumor extension. Intra-cardiac involvement with HCC rarely develops with a very poor prognosis. The occurrence and recurrence of HCC in cirrhotic patients treated with direct-acting antiviral (DAA) therapy (sofosbuvir) have been discussed in a few trials so far with no valid answer.Case presentationWe are reporting a case of recurrent HCC with an accidentally discovered direct right atrial extension with tumor thrombus through the inferior vena cava (IVC) in a cirrhotic patient previously treated with DAA. Unfortunately, due to his critical general condition, he died within days.ConclusionCardiac involvement in HCC rarely occurs and usually develops in advanced stages of HCC with very poor reported prognosis. Data regarding the relation between DAA and HCC development is controversial.
Highlights
Hepatocellular carcinoma (HCC) is considered the third-leading cause of cancer-related mortality worldwide
We are reporting a case of intracardiac extension of recurrent HCC in a previously treated hepatitis C virus (HCV) with direct-acting antiviral (DAA) with a brief review of cardiac metastasis of HCC and debatable data related to DAA and occurrence of HCC
Case report A 52-year-old hepatitis C virus (HCV)-positive male is our patient with a known history of transarterial chemoembolization (TACE) for HCC two times, 2 years and one and a half year ago
Summary
Cardiac involvement in HCC rarely occurs and usually develops in advanced stages of HCC with very poor reported prognosis.
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