Abstract
The major risk factors of hepatocellular carcinoma (HCC) include hepatitis B virus (HBV), hepatitis C virus (HCV) infec-tion and alcohol in Korea, but the prevalence of non-alcoholic fatty liver disease (NAFLD)-related HCC is rising worldwide, as 4~22% of HCC cases in Western countries are now attributed to NAFLD [1,2]. Most cases of non-alcoholic steatohepatitis (NASH), an ad-vanced form of NAFLD, do not have poor outcomes, but ad-vancement to liver fibrosis is noted in around 30% of patients and liver cirrhosis develops within 5.6 years in approximately 9% of patients. Among these patients with liver cirrhosis, 4% to 27% eventually develop HCC [3]. Recently, cases of HCC in patients with non-cirrhotic NASH have been reported [4,5]. However, HCC development in patients with NASH who do not first develop liver cirrhosis is rare and has not been previously reported in Korea. Here, we report the first known case of HCC development in a Korean patient with non-cirrhotic NASH.
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