Abstract
BackgroundGlossogyne tenuifolia (GT) is a traditional herbal tea in Penghu Island, Taiwan. Its extract is traditionally been used as an antipyretic, hepatoprotective and anti-inflammatory remedy in folk medicine among local residents. The present study investigated whether GT could improve streptozotocin-induced acute liver injury of type 2 diabetes mellitus.MethodsMale Wistar rats aged eight weeks were induced to be hyperglycemic by the subcutaneous injection of streptozotocin-nicotinamide (STZ-NA) and a combination of a high-fat diet (HFD) (N group). The animals were given GT extracts at a low dose (50 mg/kg) (L group) or a high dose (150 mg/kg) (H group) or an anti-diabetic drug (acarbose) (P group) in drinking water for 4 weeks.ResultsThe results revealed that STZ-NA increased hepatomegaly, hepatocyte cross-sectional area, hypertrophy-related pathways (IL6/STAT3-MEK5-ERK5, NFATc3, p38 and JNK MAPK), proapoptotic molecules (cytochrome C, cleaved caspase-3), and fibrosis-related pathways (FGF-2, pERK1/2). These pathway components were then expressed at lower levels in the L and H group when compared with the N group. The liver-protective effect of GT in STZ-NA-induced diabetic rats with hyperlipidemia was through an enhancement in the activation of the compensatory PI3K-Akt and Bcl2 survival-related pathway.ConclusionThe results demonstrate that the hot water extracts of GT efficiently ameliorates the STZ-NA-induced diabetes associated liver damage in rat models.
Highlights
Glossogyne tenuifolia (GT) is a traditional herbal tea in Penghu Island, Taiwan
The fasting plasma glucose levels were significantly high in the STZ-NA administered rats which was regulated to that of the normal levels in the treatment groups (Fig. 2b)
High fat diet fed diabetic rats showed other symptoms of non-alcoholic fatty liver disease (NAFLD) as seen from the elevated plasma TG and High-density lipoprotein (HDL) levels (Fig. 2d, e) but the levels in the rats treated with high and low doses of GT and in those treated with acarbose remained similar to that of the normal controls
Summary
Glossogyne tenuifolia (GT) is a traditional herbal tea in Penghu Island, Taiwan. Its extract is traditionally been used as an antipyretic, hepatoprotective and anti-inflammatory remedy in folk medicine among local residents. The present study investigated whether GT could improve streptozotocin-induced acute liver injury of type 2 diabetes mellitus. Diabetes mellitus (DM) is a chronic metabolic disease with high prevalence rate that has raised global public health concern. The resulting hyperglycemia, a major feature of DM, causes oxidative stress and various organ damages leading to disorders such as diabetic retinopathy, Most among the numerous risk factors of non-alcoholic fatty liver disease (NAFLD) causes metabolic imbalances or insulin resistance to trigger the development of diabetes [6,7,8,9]. NAFLD is known to develop into chronic liver disease in obese individuals [10]. Inhibition of Asokan et al BMC Complementary and Alternative Medicine (2019) 19:117 hepatic-apoptosis is a prospective strategy in the treatment for NAFLD
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