Hepato Effect of Argel Herb (Solenostemma argel) against Carbon Tetra Chloride Induced Liver damage in Albino Rats.

Abstract

Agral (Solenostemma argel) is a traditional edible herb that is commonly used in folkloric medicine for the treatment of rheumatic pain, inflammation, hyperlipidemia, hyperglycemia and antimicrobial agent due to its rich in bioactive component which act as antioxidants.Forty-eight male albino rats were used in biological experiments. Rats werefed the basal diet for two weeks prior to conducting the experiment. Initially, rats divided into six main groups and fed on rations for 42 days as follows: the negative control group (the first group) was fed on the basal diet. Forty male albino ratswere fed on a basic diet and stimulated with carbon tetra chloride (CCl4( in paraffin oil (50% v/v, 2 mL/Kg) twice a week by subcutaneous injection to induce chronic liver damage, then divided into 6 groups numbered from group 2 to group 6. Rats of the positive control group were fed basal diet until the final experiment. Group 3 and 4 rats were treated with dry leaves (0.5g and1.0g, respectively) of Argel. In addition, group 5 and 6 were fed on 50 ppm and 100 ppm of hydroethanolic extracts orally, respectively. Biochemical analyses as serum ALT, AST, ALP and MDA were significant decreased in rats fed on dried and extracts in Argel compared to positive group. In Contrast, it could be that SOD activity in rat groups was significant increased compared to positive group. Also, Argel extracts had highest effect for liver parameters than dried Argel.These results are concluded that Argel could be suggested to the hepatoprotective effect of Argel may be due to its antioxidants content and free radical scavenging effect.