Abstract
BackgroundStudies investigating the association between Hepatitis B virus (HBV) and hepatitis C virus (HCV) infections and intrahepatic cholangiocarcinoma (ICC) have reported inconsistent findings. We conducted a meta-analysis of epidemiological studies to explore this relationship.MethodsA comprehensive search was conducted to identify the eligible studies of hepatitis infections and ICC risk up to September 2011. Summary odds ratios (OR) with their 95% confidence intervals (95% CI) were calculated with random-effects models using Review Manager version 5.0.ResultsThirteen case–control studies and 3 cohort studies were included in the final analysis. The combined risk estimate of all studies showed statistically significant increased risk of ICC incidence with HBV and HCV infection (OR = 3.17, 95% CI, 1.88-5.34, and OR = 3.42, 95% CI, 1.96-5.99, respectively). For case–control studies alone, the combined OR of infection with HBV and HCV were 2.86 (95% CI, 1.60-5.11) and 3.63 (95% CI, 1.86-7.05), respectively, and for cohort studies alone, the OR of HBV and HCV infection were 5.39 (95% CI, 2.34-12.44) and 2.60 (95% CI, 1.36-4.97), respectively.ConclusionsThis study suggests that both HBV and HCV infection are associated with an increased risk of ICC.
Highlights
Studies investigating the association between Hepatitis B virus (HBV) and hepatitis C virus (HCV) infections and intrahepatic cholangiocarcinoma (ICC) have reported inconsistent findings
Intrahepatic cholangiocarcinoma (ICC), which originates from intrahepatic bile ducts, is the second commonest primary hepatic tumour behind hepatocellular carcinoma (HCC), accounting for 3% of all gastrointestinal cancers worldwide [1]
The etiology of ICC is poorly understood several etiological factors, including hepatolithiasis [2], primary sclerosing cholangitis [3], liver flukes (Clonorchis sinensis and Opisthorchis viverrini) [4] and exposure to the radiopaque medium thorium dioxide (Thorotrast) [5], has been well established
Summary
Studies investigating the association between Hepatitis B virus (HBV) and hepatitis C virus (HCV) infections and intrahepatic cholangiocarcinoma (ICC) have reported inconsistent findings. Intrahepatic cholangiocarcinoma (ICC), which originates from intrahepatic bile ducts, is the second commonest primary hepatic tumour behind hepatocellular carcinoma (HCC), accounting for 3% of all gastrointestinal cancers worldwide [1]. The etiology of ICC is poorly understood several etiological factors, including hepatolithiasis [2], primary sclerosing cholangitis [3], liver flukes (Clonorchis sinensis and Opisthorchis viverrini) [4] and exposure to the radiopaque medium thorium dioxide (Thorotrast) [5], has been well established. It has been shown that Hepatitis B virus (HBV) and hepatitis C virus (HCV) infections are the major causative agent for HCC [6].
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