Abstract

Hepatitis E virus (HEV) is a zoonotic virus for which pigs are the primary animal reservoir. To investigate whether HEV occurs in mink in Denmark, we screened feces and tissues from domestic and wild mink. Our finding of a novel HEV variant supports previous findings of HEV variants in a variety of species.

Highlights

  • General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights

  • In 1997, Hepatitis E virus (HEV) was discovered in pigs [1], and several studies have since shown that HEV is endemic in pigs and that pigs probably are a major animal reservoir

  • We aimed to investigate whether mink in Denmark are infected with HEV G1–G4 or other HEV variants by screening fecal and tissue samples from domestic and wild mink

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Summary

Introduction

General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights. Hepatitis E virus (HEV, family Hepeviridae) is a main cause of acute liver inflammation in humans. It is a nonenveloped RNA virus with a positive-sense genome of ≈7.2 kb. Along with the human and porcine variants, avian HEV (aHEV) has been characterized. It is widespread globally and has been proposed to comprise 3 genotypes [3]. Because HEV is highly prevalent in swine in Denmark, animals fed offal from Danish slaughterhouses will be exposed to HEV. We aimed to investigate whether mink in Denmark are infected with HEV G1–G4 or other HEV variants by screening fecal and tissue samples from domestic and wild mink

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