Abstract
To determine whether hepatitis E virus (HEV) is a cause of hepatitis among HIV-infected persons, we evaluated 1985–2009 data for US military beneficiaries. Evidence of acute or prior HEV infection was detected for 7 (4%) and 5 (3%) of 194 HIV-infected persons, respectively. HEV might be a cause of acute hepatitis among HIV-infected persons.
Highlights
Among immunosuppressed persons in industrialized countries, hepatitis E virus (HEV) is a cause of sporadic acute viral hepatitis and chronic hepatitis [1,2]
For the 7 participants with acute HEV infection (Table 2), HEV was not considered during the ALT increase, and HEV testing was not conducted as part of clinical care
HEV infection accounted for 4% of acute liver abnormalities among HIV-infected persons
Summary
Evidence of acute HEV infection at time of ALT spike (Figure 2). HEV was deemed not to be the cause of the ALT spike for 5 participants with evidence of prior HEV infection because IgG positivity preceded the ALT increase. For 1 participant, IgM was found in only 1 sample; all other samples were negative for IgM, IgG, and HEV RNA. For the 7 participants with acute HEV infection (Table 2), HEV was not considered during the ALT increase, and HEV testing was not conducted as part of clinical care. No significant differences in clinical or laboratory characteristics were found among the 7 participants with acute HEV infection and those without evidence of HEV infection (data not shown).
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
