Abstract
To the Editor: Hepatitis E virus (HEV) is a major cause of acute hepatitis in developing countries, but remains infrequent in industrialized countries despite a growing number of cases1. It is a zoonosis related to domestic and also wild animals. In epidemic conditions HEV is transmitted mainly by drinking fecal-contaminated water, but it can also be transmitted person to person, or mother to fetus, and even through contaminated transfusions. Sporadic hepatitis E seems to be the most common manifestation in industrialized countries2. In France, genotype 3 is the most common. HEV infection is usually self-limited, symptomatic or asymptomatic, with possible acute hepatitis. Fulminant hepatitis may be observed in pregnant women and patients with underlying liver disease. Chronic infections can be detected in patients with transplants, lymphoma, leukemia with reactivation, in immunocompromised children, and in patients infected with human immunodeficiency virus. We describe a patient with rheumatoid arthritis (RA), treated with rituximab (RTX) and methotrexate (MTX), … Address correspondence to Dr. Roux; E-mail: roux101fr{at}yahoo.fr
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