Abstract
Objective: Lymphocytes play an important role in the pathogenesis of chronic viral hepatitis. Apart from intrahepatic replication of hepatitis C Virus (HCV), there is also strong evidence for an extrahepatic site in mononuclear blood cells. To further characterize the site of HCV replication, we tested resting peripheral blood lymphocytes (PBL) and stimulated PBL for the presence of positive- and negative-stranded HCV RNA. Method: PBL from 10 patients with histologically proven chronic active hepatitis C were sorted into CD4+ (T helper) and CD8+ (T suppressor) T cells, CD20+ B cells and CD16+ natural killer (NK) cells by a fluorescence-activated cell sorter. Results: HCV RNA was detected by a nested polymerase chain reaction
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