Abstract
<p><span style="font-size: 10.5pt; font-family: 'Times New Roman','serif'; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0pt; mso-ansi-language: EN-US; mso-fareast-language: ZH-CN; mso-bidi-language: AR-SA; mso-bidi-font-size: 12.0pt;" lang="EN-US">Six major hepatitis C virus genotypes have been characterized, which vary in their geographical distribution. Knowledge of the distribution of various genotypes is essential for successful future research, treatment and control strategies. In this study, the distribution of HCV genotypes and their association with possible risk factors in a group of HCV infected patients from Kermanshah province of Iran was investigated. HCV viral load test by Real time- PCR method was used for diagnosis of infected cases. The genotypes of cases were revealed using Nested- and Multiplex-PCR and with direct sequencing results were confirmed. Risk factors were also recorded and a multivariate analysis was performed. Among 180 infected people, 138 (76.6%) with 3a genotype, 35 (19.4%) with 1a genotype, 3 (1.7%) with 1b genotype and 4 (2.2%) with 3a and 1b were determined. HCV was transmitted by different routes such as intravenous drug abuse (IVDA), tattooing, sexual, blood transfusion and other risk factors. IVDA and sex are the main risk factors in the men and women, respectively. However, 3a is the predominant genotype in the all groups. This study revealed that 3a is the most prevalent genotypes in Kermanshah province.</span></p>
Highlights
Infection to Hepatitis C virus (HCV) is one of the critical health problems worldwide
There is a notable statistic; from 180 infected patients, 146 cases (81.1%) were connected with suspicious blood; 96 cases were addicted (IVDA), 43 cases had history of tattoo, 5 cases were health center staff, 2 cases had hemophilia and 34 cases (18.9%) have unknown risk factors (Figure 2) that maybe is related to high risk sexual behavior that didn’t declare because of cultural reasons
One important thing in the mentioned data is that 7 cases means 3.9% of total patients, 5 cases of Health staffs and 2 hemophilia cases, are infected due to fault in Health systems because frequency of HCV infection in normal population is 0.5-1% (Merat et al, 2010)
Summary
Infection to Hepatitis C virus (HCV) is one of the critical health problems worldwide. HCV infection is one of the main causes of chronic viral hepatitis, hepatocellular carcinoma and cirrhosis (Martins et al, 2011). HCV is the leading reason for liver transplantation in the United States and it is controversial concepts in organ shortage (Zein, 2000). More than one million infected new cases are reported in world (Cooreman & Schoondermark Van, 1996). The incidence of new HCV infection is declining, at least in industrialized countries, yet HCV infection with an estimated prevalence of 3% in the world population is known as heavily burdens public health (Pol et al, 2012)
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