Hepatitis C Infection and Chronic Renal Diseases: A Systematic Review

Abstract

A connection was reported between hepatitis C virus (HCV) and chronic kidney disease (CKD). A viral infection can be both a cause and a consequence of CKD. HCV infection is associated with a greater incidence of diabetes mellitus and CKD and a higher risk of systemic (particularly cardiovascular) effects because HCV infection increases the chance of illness developing. Although the fundamental symptom of HCV-induced glomerulonephritis has been well documented, the virus has been related to CKD in various ways, i.e., new evidence points to a connection between HCV infection and CKD onset, as well as the rapid advancement of CKD to end-stage renal disease, which calls for kidney transplantation or hemodialysis. An HCV infection dramatically increased a person's risk of developing CKD, which can lead to kidney failure. Compared with patients with HCV infection and existing CKD, those with HCV infection who had normal renal function had greater odds of renal progression. The administration of anti-hepatitis medication can result in variations in the estimated glomerular filtration rate, which can either lead to an improvement or a worsening of the patient's health, depending on which direction the variation goes.