Hepatitis B Virus Reactivation in a Patient With Resolved Hepatitis B Virus Infection Receiving Maintenance Rituximab for Malignant B-Cell Lymphoma

Abstract

Letters5 May 2009Hepatitis B Virus Reactivation in a Patient With Resolved Hepatitis B Virus Infection Receiving Maintenance Rituximab for Malignant B-Cell LymphomaYu Xuan Koo, Daniel S.W. Tan, MBBS, Iain B. Tan, MBBS, Miriam Tao, MBBS, and Soon Thye Lim, MBBSYu Xuan KooFrom Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, and National Cancer Centre Singapore, Singapore 169610.Search for more papers by this author, Daniel S.W. Tan, MBBSFrom Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, and National Cancer Centre Singapore, Singapore 169610.Search for more papers by this author, Iain B. Tan, MBBSFrom Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, and National Cancer Centre Singapore, Singapore 169610.Search for more papers by this author, Miriam Tao, MBBSFrom Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, and National Cancer Centre Singapore, Singapore 169610.Search for more papers by this author, and Soon Thye Lim, MBBSFrom Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, and National Cancer Centre Singapore, Singapore 169610.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-150-9-200905050-00024 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Background: The risk for hepatitis B virus (HBV) reactivation in patients with seemingly resolved infection who are undergoing treatment for cancer remains controversial.Objective: To report a case of HBV reactivation in a patient with seemingly resolved infection who was undergoing lymphoma treatment.Case Report: A 71-year-old man with mantle cell lymphoma had previously resolved hepatitis B virus (HBV) infection, defined as negative HBV surface antigen (HBsAg) with detectable antibody to HBV core antigen (anti-HBc). He had no detectable antibody to HBsAg (anti-HBsAg). Full staging investigations showed multiple enlarged lymph nodes. An excision biopsy of the right axillary lymph node ...