Abstract
Virological diagnosis and monitoring of hepatitis B virus (HBV) infection are based on serologic assays detecting specific anti-HBV antibodies, and assays that can detect, quantify or characterize the components of HBV viral particles, such as HBV DNA and various viral antigens. HBV DNA detection and quantification now play a key role in the diagnosis of infection, therapeutic decision-making, and assessment of the response to therapy. However, clinically relevant HBV DNA thresholds remain to be established in various settings. HBV DNA quantification can also be used to monitor viral replication kinetics to better understand the mechanisms of infection and the virologic response to antiviral therapy.
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