Abstract
Hepatitis B Vaccines and HPV Vaccines Have Been Hailed as Major Public Health Achievements in Preventing Cancer--Could a Schistosomiasis Vaccine be the Third?
Highlights
People become infected with Schistosoma haematobium, the etiologic agent of urogenital schistosomiasis, when they are exposed to fresh water infested by Bulinus snails that release cercariae
We contend that a successful vaccine for urogenital schistosomiasis may confer major public health benefits by preventing bladder cancer
Given that both S. haematobium and human papillomavirus (HPV) cause urogenital cancers, and an efficacious HPV vaccine has been successfully developed and implemented, we may be able to glean important lessons relevant to cancer prevention using a vaccine for urogenital schistosomiasis
Summary
No approved human vaccine exists to prevent or treat schistosomiasis. People become infected with Schistosoma haematobium, the etiologic agent of urogenital schistosomiasis, when they are exposed to fresh water infested by Bulinus snails that release cercariae. After burrowing through the skin of human hosts, cercariae develop into egg-laying adults.
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