Abstract
A comprehensive epidemiological analysis of hepatitis B virus (HBV) endemicity and transmission in Latin America was carried out to suggest policies and strategies for the use of hepatitis B vaccine in the region. The pattern of HBV endemicity based on available data from blood bank screening programmes and clinical and epidemiological studies varied widely: it was low in temperature South America, Mexico and some Caribbean islands; moderate in Brazil, Andean countries, part of central American and the Carribean; and high in Hispaniola, St. Kitts/Nevis and in the Amazon basin (parts of Brazil, Peru, Venezuela, Colombia). Statistical estimates of HBV_related morbidity showed that > 150 000 acute HBV cases occur per year. As the endemicity of HBV varies considerably, different prevention strategies should be applied in this area. The highest priority should be the prevention of perinatal and early childhood transmission, but vaccination of adults belonging to high-risk groups should also be recommended.
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