Abstract
Ultrastructural changes in rat hepatocytes begin within 5 minutes of fructose infusion. The earliest detectable change is a rarefaction of the hyaloplasm which rapidly increases, and is apparently due to overhydration or edema. It is not accompanied by swelling of mitochondria or alteration in the density of the matrix. The smooth endoplasmic reticulum forms large nodular masses near the periphery of the cell; presumably by redistribution of the agranular reticulum rather than by new formation of membrane. The Golgi zones become extremely small and simplified. The cisternae of the rough endoplasmic reticulum show disarray, and segmental loss of ribosomes, and contribute to the formation of membranous whorls. It is suggested that many of these changes are due to the sudden drop in ATP which is known to occur in acute fructose loading.
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