Abstract
Fourty heterozygotic rats received Na2SeO4 (10 mg per kg of food). Out of 23 rats, which survived for over 18 months, the tumors developed in 10: in 3 cases there was cancer of the liver (in 2 rats—metastases into the lungs), in 4—sarcoma, and in 3—hepatic-cellular adenoma. Addition of riboflavinto the diet (10 mg daily), beginning from the 7th month of the experiment, did not change the pathological process. A suggestion is made that the blastomogenic effect of selenium is connected with the fact that it is methionine antimetabolite and the mechanism of its action is possibly very similar to that of ethionine.
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