Abstract
Plasma triglyceride concentrations were significantly lowered by a single feeding of glucose to rats that had been fasted for 22 hr. Three feedings of glucose produced a similar effect. In the glucose-refed animals mobilization of free fatty acids from adipose tissue was impaired more rapidly than hepatic lipogenesis was restored from its low fasting level. These effects of glucose were shown by both a 50% fall in plasma free fatty acid concentration and an 84% decrease in free fatty acid release by isolated epididymal fat pads within 30 min after a single refeeding of glucose. Hepatic lipogenesis from either acetate-1-(14)C or glucose-U-(14)C was not restored even after glucose had been fed three times at hourly intervals. Triton-induced hypertriglyceridemia was used to measure the hepatic triglyceride secretory rate; it was found that glucose refeeding decreased this rate in all but one of several experiments. This decreased secretion rate was sufficient to account for the nearly complete disappearance of triglyceride in very low density lipoproteins (d < 1.019) that occurred within 1 hr after a single glucose intubation.
Highlights
Plasma triglyceride concentrations were significantly lowered by a single feeding of glucose to rats that had been fasted for 22 hr
Have1 [8] has suggested that after glucose ingestion the increased uptake of plasma T G by tissues could account for the phenomenon, which he had observed in man
Plasma T G levels did not change during the experiment in untreated fasted rats (Fig. 1, Expt. 11).Feeding a glucose solution three times lowered serum or plasma TG
Summary
Plasma triglyceride concentrations were significantly lowered by a single feeding of glucose to rats that had been fasted for 22 hr. In the glucose-refed animals mobilization of free fatty acids from adipose tissue was impaired more rapidly than hepatic lipogenesiswas restored from its low fasting level. These effects of glucose were shown by both a 50% fall in plasma free fatty acid concentration and an 84% decrease in free fatty acid release by isolated epididymal fat pads within 30 min after a single refeeding of glucose. Have1 [8] has suggested that after glucose ingestion the increased uptake of plasma T G by tissues could account for the phenomenon, which he had observed in man His explanation, did not place any emphasis upon the nutritional state of the subject prior to glucose feeding. In nonfasted human subjects or animals, carbohydrate feeding either does not affect or increases plasma T G [7, 9,10,11,12,13,14].'
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