Abstract
THE histochemical detection of early changes in the characteristics, distribution and enzyme contents of lysosomes, as well as their cycles of appearance and disappearance, affords a sensitive index of toxic effects on the cell. Hypoxia is known to labilize lysosomes1 and might be expected to render them more susceptible to adverse influences. Selective uptake of neutral red by lysosomes2,3 and the stabilization brought about by chloroquine4 constitute further experimental manipulations to which lysosomes can be subjected. We have made detailed observations of lysosomal behaviour in these conditions as a preliminary to the study of lysosomal changes in the damaged liver of the rat.
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