Abstract
1. The microsomal MFO activity of mallard ducks, Anas platyrhynchos, showed a pH optimum for aminopyrine N-demethylation at 7.2–7.3 and for benzo(a)pyrene hydroxylation at 6.8. The optimum temperature for N-demthylation of aminopyrine, at 7.2 pH, lay between 42 and 45°C. 2. The Lineweaver-Burk plot of kinetic data for the N-demethylation of aminopyrine showed a departure from linearity which may indicate the presence of more than one enzyme acting on this substrate. 3. Male rats have twice the cytochrome P450 and N-demethylase activity than male ducks, but female ducks are 4 times more active in benzo(a)pyrene hydroxylation than male rats.
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