Abstract
Hepatic microsomes prepared from red-winged blackbirds ( Agelaius phoeniceus ) and albino rats were incubated with N , N -dimethylaniline (DMA)_in complete incubation mixtures at pH 7.9 and 37°C for 10 min. Formaldehyde and N , N -dimethylaniline- N -oxide produced from DMA were measured. Redwings were found to have significantly lower N -demethylation activities than rats, and redwings had only marginal or no N -oxidation activities. Hepatic microsomes from redwings did not further metabolize the N -oxide. The N -oxidation and N -demethylation activities of brown-headed cowbirds ( Molothrus ater ), common grackles ( Quiscalus quiscula ), and starlings ( Sturnus vulgaris ) were similar to those of redwings.
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