Abstract
The mechanism of hepatic microsomal enzyme induction produced by inhalation anesthetics was examined in rats. Diethyl ether (1.6 per cent, 7 hours/day for five days) is a true inducing agent, qualitatively similar to phenobarbital. It increases cytochrome P–450, cytochrome bs, NADPH cytochrome c reductase, microsomal prottein, and biotransformation of several drugs. The time course of the induction process with diethyl ether is similar to that with phenobarbital. Methoxyflurane is not a microsomal enzyme-inducing agent in the same respect. It enhances biotransformation of only certain drugs by a nonspecific stimulation which may be related to decreased catabolism of microsomal NADPH cytochrome c reductase.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
