Hepatic histopathological changes of exercise and antioxidant administration on postprandial dysmetabolism.

Abstract

Metabolic syndrome incidence is increasing, especially in industrialized countries. Lack of exercise and obesity are a major cause of morbidity and mortality at ages becoming younger. Exercise is proven to be a cardiovascular protective factor. Oxidant-antioxidant balance is modified with the advent of any pathological process. The aim of the study was to observe the effect antioxidant administration (coenzyme Q10) has in different types of diet and at different activity status. Research was conducted on male Wistar rats, divided into 12 groups of 10 animals, in two 6 lots stages. Animals received in the first stage the normal diet (I, II), high-sugar diet (III, IV), high-fat diet(V, VI), were carried out daily exercise (II, IV, VI) or were sedentary (I, III, V ). During the second stage, study model conducted in the first stage was added oral coenzyme Q10 gavage(100mg/kgc). After 28 days, the animals were euthanized and the liver was collected. Histopathological examination of liver biopsies not revealed significant changes in terms of steatosis, inflammation or macular degeneration regardless of diet, supplementation with coenzyme Q10 or performing exercise.