Hepatic epithelioid angiomyolipoma: clinical features and imaging findings of contrast-enhanced ultrasound and CT

Abstract

To evaluate the clinical features and imaging findings of epithelioid angiomyolipoma (EAML) on contrast-enhanced ultrasound (CEUS) and contrast-enhanced computed tomography (CECT). During January 2006 to November 2015, six patients with histopathologically proven hepatic EAML were evaluated using both CECT and ultrasonography. Six patients underwent CEUS and four patients had CECT images. Patients' demographics, clinical presentations, laboratory test results, and imaging appearances were collected and analysed. Six patients were female, and the mean age was 43.5 years. All hepatic EAMLs were solitary. None of patients had specific symptoms, and laboratory tests were normal in all patients. The maximal diameter of the lesions ranged from 3.1 to 6.5cm (mean 4.4cm). Baseline ultrasound revealed that 50% of hepatic EAMLs were hypo-echoic and 50% were mixed echoic. CEUS showed that 100% of the hepatic EAMLs displayed homogeneous hyperenhancement in the arterial phase and 67% (4/6) showed hypo-enhancement in the late phase. On CECT, 100% (4/4) of the neoplasms were significantly hyperenhanced in the arterial phase and washout in the portal phase. There was no recurrence or metastasis after a mean follow-up period of 11.8 months. Hepatic EAML shows similar enhancement patterns to that of hepatocellular carcinoma. It should be considered as a possible differential diagnosis in female patients without viral hepatitis infection.