Abstract
The rates of metabolism in vitro of pentobarbital, aminopyrine and p-nitrobenzoic acid were significantly reduced and the duration of action of pentobarbital in vivo was prolonged in zinc-deficient rats. Zinc deficiency did not result in an alteration in the rate of aromatic ring hydroxylaiion in vitro, with either aniline or zoxazolamine as substrate. Microsomal protein and RNA levels were maintained during zinc depletion, but a significant decrease in the cytochrome P-450 content of the microsomes was noted in zinc-deficient rats at approximately the same time as the lower rate in metabolism of pentobarbital was found. Biochemical lesions and gross signs of zinc deficiency were completely ameliorated by refeeding zinc-deficient rats a zinc-containing diet for 14 days.
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