Abstract
The basal values for hepatic microsomal enzyme activity in Merino ewes were higher per milligram of microsomal protein than those in female Wistar rats for para-nitroreductase, aminopyrine, and para-nitroanisole demethylases, but slightly lower for aniline para-hydroxylase. Vitamin E deficiency did not alter these parameters significantly, although there was a slight increase in NADPH oxidase activity. Pretreatment with phenobarbital gave significant increases in cytochrome P-450 and the other enzymes associated with microsomal drug metabolism. The exceptions were a significant reduction in the content of cytochrome b 5 and a slight reduction in NADPH cytochrome c reductase activity. The addition of 10 −3 m flavine mononucleotide (FMN) to the incubation media elevated the otherwise low levels of nitroreductase activity approximately 11-fold.
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