Abstract
To evaluate hepatic morphological-histological abnormalities in newborns from female rats exposed to ethylenethiourea. A randomized study was conducted on fifty-five newborn Wistar rats were studied: 34 in the experimental group, whose mothers had been exposed to 1% ethylenethiourea; and 21 in the control group, whose mothers had received 0.9% physiological solution. The solution was administered via gavage on the 11(th) day of gestation. Cesarean section was performed on the 20(th) day of gestation. The newborns' livers were examined and any morphological-histological abnormalities were registered. The presence of megakaryocytes was quantified in 50 microscope fields, as the total number of these cells per mm(2). The entire experimental group presented abnormalities of embryonic formation, with musculoskeletal anomalies, digestive system anomalies, hepatic congestion and friability, hydrops and delayed intrauterine growth. The histopathological analysis showed that morphological-histological hepatic destructuring had occurred in all entire experimental with removal of the hepatic trabeculae and severe hepatic megakaryocytosis. The mean megakaryocyte density ranged from 107.9 to 114.2 per mm(2), and it was eight times greater than in the control group, thus characterizing a situation of extramedullary hematopoiesis. The fetal exposure to ethylenethiourea caused hepatic damage characterized by severe extramedullary hematopoiesis.
Highlights
With increasing need for food production from agriculture, pesticide use has been increasing
Descriptive analysis was performed on the data in order to identify any visual differences between the control and experimental groups
The groups were compared in relation to fetal hydrops and the macroscopic description of the liver
Summary
With increasing need for food production from agriculture, pesticide use has been increasing. This has been occurring irregularly, without adequate control by government bodies[1]. This inadequate control gives rise to risks of environmental contamination and risks to human health caused by exposure to these substances[1,2]. Developing countries are responsible for consuming 30% of the pesticides produced worldwide[3]. In Brazil, this growth in consumption over recent decades has transformed the country into one of the world leaders of pesticide use[4]
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