HEPATIC DAMAGE ASSOCIATED WITH SULFONAMIDE THERAPY IN INFANTS AND CHILDREN. I. MORPHOLOGIC PATHOLOGY

Abstract

Article1 October 1943HEPATIC DAMAGE ASSOCIATED WITH SULFONAMIDE THERAPY IN INFANTS AND CHILDREN. I. MORPHOLOGIC PATHOLOGYMAUD L. MENTEN, M.D., PH.D., F.A.C.P., MARIE A. ANDERSCH, PH.D.MAUD L. MENTEN, M.D., PH.D., F.A.C.P.Search for more papers by this author, MARIE A. ANDERSCH, PH.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-19-4-609 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe introduction of the sulfonamides into chemotherapy undoubtedly has reduced appreciably the mortality rate of many infections. However, certain untoward effects were not unexpected because of the inherent toxicity of these drugs and because of individual idiosyncrasy. A number of clinical reports have appeared regarding the deleterious effects of the sulfonamides on the hematopoietic system and the urinary tract. Toxic effects on the liver, as indicated by the development of jaundice, have been of less frequent occurrence. Varying degrees of pathologic change have been found by us in the liver of several infants and children dying during the course of...Bibliography1. HAGERMANBLAKE POFG: A febrile reaction to sulfanilamide; drug fever, Jr. Am. Med. Assoc., 1937, cix, 642-646. CrossrefGoogle Scholar2. SAPHIRSTEIN H: Hepatitis and toxic erythema with desquamation due to sulfanilamide, Urol. and Cutan. Rev., 1938, xxxxii, 101-102. Google Scholar3. LONG PH: The clinical use of sulfanilamide and its derivatives with special reference to their possible toxic effects, Jr. Ohio Med. Assoc., 1938, xxxiv, 977-981. Google Scholar4. BANNICKBROWNFOSTER EGAEFP: Therapeutic effectiveness and toxicity of sulfanilamide and several related compounds, Jr. Am. Med. Assoc., 1938, cxi, 770-777. CrossrefGoogle Scholar5. GARVIN CF: Toxic hepatitis due to sulfanilamide, Jr. Am. Med. Assoc., 1938, cxi, 2283-2285. 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Author, Article, and Disclosure InformationAffiliations: Pittsburgh, Pennsylvania*Received for publication June 29, 1942.From the Pathological Laboratories, University of Pittsburgh and Children's Hospital, Pittsburgh, Pennsylvania. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDrug-Induced JaundiceCholangiolitic HepatitisSTREPTOMYCIN AND PROMIZOLE IN MILIARY TUBERCULOSIS AND TUBERCULOUS MENINGITIS IN CHILDREN 1 October 1943Volume 19, Issue 4Page: 609-621KeywordsAdverse reactionsChemotherapyChildrenDeath ratesInfantsLiverSulfonamideToxicity ePublished: 1 December 2008 Issue Published: 1 October 1943 PDF downloadLoading ...