Abstract
The role of the liver in the total metabolic clearance of growth hormone from plasma in man was evaluated using HGH 131I and the constant infusion to equilibrium technique. Five normal subjects and four patients with cirrhosis and portal hypertension were studied after an overnight fast. HGH 131I was infused into an antecubital vein and blood samples were obtained at equilibrium from a brachial artery and hepatic vein and assayed for immunoprecipitable HGH 131I. Hepatic plasma flow was determined using in-docyanine green by the Fick calculations. The mean metabolic clearance rate (MCR) for the normal subjects was 147 ± 22 ml/min; the mean hepatic clearance of GH (CH) was 139 ± 13 ml/min. The CH represented 95 ± 6% of the total MCR. The mean hepatic plasma flow of the patients with cirrhosis was reduced when compared to the normal group, 880 ± 131 vs. 1037 ± 91 ml/min, p < 0.05. The cirrhotic patients MCR, 169 ± 27 ml/min, CH 124 ± 20 ml/min, and CH percent of MCR 76 ± 21 did not differ from the normal gro...
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