Abstract
Nonalcoholic fatty liver disease (NAFLD) is the leading cause of liver disease in children aged 2 to 19 years. It is defined as excessive deposition of fat in the liver leading to macrovesicular hepatic steatosis. This disease ranges from simple steatosis to nonalcoholic steatohepatitis (NASH) with active inflammation and finally to end-stage cirrhosis. The major risk factor for NAFLD in children is obesity. The prevalence of NAFLD in these children is estimated to be between 8% and 23% in the United States. These wide discrepancies in prevalence rates are due to utilization of varying diagnostic criteria, including the absence of histopathological evidence, which is still considered the gold standard in establishing the diagnosis of NAFLD. Although fibrosis is common in pediatric NASH, cirrhosis has been described in only a few cases of childhood NAFLD. We describe a girl with childhood onset obesity presenting with hepatic cirrhosis.
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