Hepatic aminopyrine N-demethylase, acetanilide hydroxylase and lipid peroxidation in young growing rats during the treatment of insecticides.

Abstract

Halogenated hydrocarbon insecticides and their metabolites are knovm to alter the activity of microsomal enzymes(HART et a1.1963, HART and FOUTS 1963, 1965, WELCH et a1.1967, BUNYAn and PAGE 1973). in contrast to the halogenated hydrocarbons there are very few reports regarding the effect of organophosphorus and carbamate insecticides on microsomal drug metabolizing enzymes. Hepatic drug metabolism has been found to be decreased by malathion in mice and rats (STEVENS et al. 1972, RA0 and ANDERS 1973, STEVENS and GREENE 1973). Very recently, STEVENS and GREENE (1974) have showed that subacute administration of insecticides resulted in induction of hepatic drug metabolism and mixed function oxidase systems in rats! however, WEBER et a1,(1974) have reoorted that parathion inhibited the metabolism of benzo(a)pyrene in rat liver and intestine. Our earlier investigations have reported an increase in drug metabolizing enzymes and lipid peroxidation during Take20 administration and a decrease in drug metabolism followed by an increased lipid peroxidation during Baygon administration in young growing rats (MAKHIJA and PAWAR 1974,1975). A literature review indicates a paucity of toxicological data and hence the present experiments were planned to investigate the effect of Take-20 (0,0dimethyl malathion) and Baygon on hepatic drug metabolism and lipid peroxidation in young growing rats.