Abstract
Intravenous heparin (450 units per kg. body-weight every 8 hours or 500 units per kg. every 6 hours) had no antimalarial activity against Plasmodium knowlesi malaria in monkeys. The survival of infected monkeys was not influenced by 450 units of heparin per kg. administered intravenously every 8 hours. Disseminated intravascular coagulation, therefore, does not seem to be the major cause of death in these animals. Routine use of heparin in complicated falciparum malaria in man must await controlled studies which demonstrate efficacy.
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