Abstract
Sulfated polysaccharides have attained a new recognition in medicine for treatment of human pathogens such as Staphylococcus aureus. By careful protecting group strategy, methacrylate derivatives of sulfated sugars containing various saccharides have been successfully produced. The position of sulfate groups as well as methyl methacrylate was varied to demonstrate the structure-activity relationship (SAR) of the resulting polymers in regards to their multivalent effect on the bacteria inhibition. The preliminary in vitro assay indicated promising inhibition of S. aureus infection in the presence of doubly sulfated polymers and suggests that our sulfated polymers might be a potential candidate to mediate S. aureus internalization.
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