Heparin Infusion to Prevent Umbilical Venous Catheter Related Thrombosis in Neonates

Abstract

ObjectiveTo investigate umbilical venous catheter (UVC) related thrombosis by Doppler echocardiographic evaluation of neonates infused with heparin or placebo. MethodsWe conducted a prospective study to determine UVC-related thrombosis in term and nearterm neonates. Heparin or placebo (0.5IU/mL) was infused at a rate of 1mL/hr to the study and control group. Doppler echocardiography was performed at 1, 3, and 5days after UVC insertion. ResultsForty-six neonates (63% males) with a mean gestational age of 38.2±1.8weeks, and a mean birth-weight of 2993±563grams were included. No UVC-related thrombosis was observed in the study group, which included 19 neonates. Among the 27 neonates in the control group, one neonate developed UVC-related thrombosis. There were no statistical differences between the groups for gestational age, birth weight, postnatal age, UVC duration, mortality, mechanical ventilation, and inotrope requirement, and hemagram or coagulation profile. The complications were as follows, mild pulmonary hemorrhage, 6.5% (3); leak-out, 4.3% (2); peritoneal leakage, 2.2% (1); occlusion, 2.2% (1); gastrointestinal findings, 6.5% (3); sepsis, 10.9% (5); and catheter-related thrombosis, 2.2% (1). ConclusionThis study demonstrated that heparin infusion of 0.5IU/mL through the UVC had no effect on catheter-related thrombosis in term and near-term neonates. Randomized controlled trials are necessary to conclusively evaluate the effect of heparin on UVC-related thrombosis.