Abstract
Purpose: Osteoarthritis (OA) is the most prevalent degenerative joint disease worldwide, characterized by an increasing degeneration of the articular cartilage. Proteoglycans (PGs) carrying chondroitin sulfate or heparan sulfate (HS) polysaccharides are major components of cartilage matrix. Nevertheless, the impact of the PG composition on the integrity of the articular cartilage and OA development remains unclear. In previous experiments we demonstrated that an altered HS structure is protective against OA.
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