Henry reaction catalyzed by recyclable polyamine

Abstract

The catalytic Henry reaction is an important CC bond forming reaction between aldehyde/ketone and nitroalkane. Herein, a metal-free recyclable polyamine JP-2Y was developed and various β- nitroalcohols were prepared with acceptable yields (up to 91%) via the Henry reaction catalyzed by JP-2Y. In addition, for nitromethane, the protocol can be used for selective preparation of β-nitro alcohols or 1,3-dinitroalkanes by adjusting the reaction temperature and additive. The recyclability of JP-2Y was proved via catalyzing the reaction at gram-scale for at least 8 consecutive runs.