Abstract
BackgroundHenoch-Schönlein purpura is a common small vessel vasculitis in children. Acute pancreatitis rarely presents as a complication of Henoch-Schönlein purpura and has not been well characterized.MethodsWe retrospectively reviewed 13 cases of Henoch-Schönlein purpura with acute pancreatitis among 3212 patients who attended our hospital between January 2003 and June 2016 and analyzed their clinical characteristics, laboratory findings, imaging findings, treatment and overall prognosis.ResultsAll patients had abdominal manifestations, including significant abdominal pain (13/13), vomiting (9/13), abdominal distension (3/13) and melena (6/13). Serum amylase level significantly increased in all patients, and urine amylase was increased in 7 cases (7/10). However, increased urine lapse was only noted in 2 cases (2/5), and diffuse swelling of the pancreas was seen in 2 cases (2/13) by abdominal ultrasonography. Although all patients had typical skin purpura (13/13), 5 patients (5/13) with acute pancreatitis initially experienced acute abdominal pain in clinical onset of Henoch-Schönlein purpura. Glucocorticoid therapy was effective in alleviating abdominal symptoms of Henoch-Schönlein purpura patients with acute pancreatitis. All patients were in good general condition without any abdominal complications 6–12 months after discharge.ConclusionsAcute pancreatitis is rarely observed in Henoch-Schönlein purpura children and has no specific clinical features that differentiate it from abdominal manifestations of Henoch-Schönlein purpura. Therefore, in Henoch-Schönlein purpura patients with severe abdominal pain, serum amylase levels should be assessed to confirm the diagnosis of acute pancreatitis. Early diagnose of Henoch-Schönlein purpura with acute pancreatitis and treatment timely was very important for good clinical outcomes.
Highlights
Henoch-Schönlein purpura is a common small vessel vasculitis in children
Among the 3212 Henoch-Schönlein purpura (HSP) patients, only 13 patients (0.4%), including 9 males and 4 females, had Acute pancreatitis (AP) as a complication of HSP
Henoch–Schönlein purpura (HSP) is a systemic vasculitis that is characterized by the deposition of IgAcontaining complex and complement component 3 (C3) on arterioles, capillaries, and venules [7]
Summary
Henoch-Schönlein purpura is a common small vessel vasculitis in children. Acute pancreatitis rarely presents as a complication of Henoch-Schönlein purpura and has not been well characterized. Henoch-Schönlein purpura (HSP), a systemic smallvessel vasculitis syndrome, typically occurs in children and causes purpuric skin lesions accompanied by various presentations, including gastrointestinal symptoms, arthritis, and nephritis [1]. Gastrointestinal manifestations occur in two-thirds of patients and vary from mild abdominal pain to colicky features [2]. Acute pancreatitis (AP) has been reported by only a limited number of authors, with different clinical features during the course of HSP. AP can be diagnosed on the basis of a high level of serum amylase in HSP patients with abdominal pain. We retrospectively reviewed 13 cases of HSP patients with AP among 3212 HSP patients and analyzed symptoms and signs, laboratory findings, imaging findings, treatment and their prognosis
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