Hemostatic system parameters and level of magnesium in patients with beta-thalassemiа

Abstract

Aim. To study the hemostatic system parameters and magnesium levels in patients with beta-thalassemia.
 Methods. The object of the study was the blood serum of 96 women with beta-thalassemia: 46 patients with intermediate beta-thalassemia and 50 patients with beta-thalassemia minor, without clinical manifestations of hypercoagulation. The blood serum of 30 healthy donors was used as the control group. It was studied hemostasis system parameters: platelet count activated partial thromboplastin time (aPTT), prothrombin time, plasma fibrinogen level, D-dimer level, euglobulin clot lysis time, antithrombin III activity. The serum magnesium level and risk of deficiency were determined using the MDQ questionnaire.
 Results. In patients with intermediate beta-thalassemia, an increase in the level of thrombinemia marker D-dimer (500 ng/ml) was revealed. Patients with intermediate beta-thalassemia were divided into two groups according to the revealed level of D-dimer: 14 (30.46.8%) patients with latent hypercoagulation in group 1 and 32 (69.66.8%) patients without latent hypercoagulation in group 2. It was found that in the group with a high levels D-dimer, fibrinogen level was increased (p 0.05), fibrinolysis time was prolonged (p 0.05), activated partial thromboplastin time was shortened (p 0.05), and antithrombin III activity was slightly reduced (p 0.05). The serum magnesium level in patients of the first group was lower (t=7.3; p 0.001), and the risk of deficiency in the questionnaire was higher than in patients of the second group (r=0.785, p 0.05). Hemostasis and magnesium levels in patients with beta-thalassemia minor did not differ from the control group (p 0.05).
 Conclusion. One-third of patients with intermediate beta-thalassemia have a pre-thrombotic state for hemostasis latent hypercoagulation and magnesium deficiency which can be predictors of clinical signs of thrombosis.