Hemostatic risk factors of coronary artery disease in the Chinese

Abstract

In order to find out the hemostatic risk factors of coronary artery disease in the Chinese, antithrombin III concentration, factor VII and fibrinogen assays, plasminogen activator inhibitor-1 antigen and platelet count were determined in 51 healthy controls (mean age 63.5 years, S.D. 10.3), 55 diabetics (mean age 66.0 years, S.D. 4.8) and 56 patients with arteriographically proved coronary artery disease (mean age 63.8 years, S.D. 8.7). Of the coronary artery disease group, 19 had single vessel disease, 21 had double vessel disease and 16 had triple vessel disease. Sixteen of this group also had a past history of myocardial infarction. There was no significant difference of the hemostasis parameters between diabetics and controls. Fibrinogen and factor VII, but not plasminogen activator inhibitor, were significantly higher in coronary artery disease patients than in controls ( P = 0.0001, both) and in diabetics ( P = 0.0001, both). No significant difference in the parameters was found in the coronary artery disease group, whether the patients had single vessel disease, double vessel disease, or triple vessel disease, or were with or without past myocardial infarction. In the myocardial infarction group, fibrinogen and factor VII were significantly higher than in the controls ( P < 0.00005 and 0.0001, respectively) and in the diabetics ( P = 0.0002 and 0.0004, respectively). We suggest that increased levels of fibrinogen and factor VII, but not plasminogen activator inhibitor, would be the hemostatic risk factors of coronary artery disease in the Chinese.