Abstract
Incomplete resection of tumor tissue and bleeding during skin cancer surgery can easily lead to early tumor recurrence and metastasis. In this study, a three-dimensional doxorubicin (DOX) loaded poly (lactic-co-glycolic acid) (PLGA) nanofibers/chitosan (CS) aerogel composite with hemostasis and chemo-photothermal effect was successfully prepared by electrospinning and lyophilization. The highly porous PLGA/MXene/DOX nanofibers@CS aerogel (PMD@CS) demonstrated exceptional photothermal conversion and pH/temperature-responsive drug release properties, which inhibited the growth of tumor cells, showing a potential chemo-photothermal effect. Furthermore, the nanofibers/aerogel composite showed desired hemostatic efficacy and biocompatibility, with a blood coagulation index of 65.1 ± 1.9% and a blood coagulation time within 3 min, indicating its potential for rapid bleeding control. This nanofibers/aerogel composite with bifunction of chemo-photothermal synergetic therapy and hemostasis can be an antineoplastic biomedical material for the prevention of postoperative tumor recurrence and metastasis.
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